Table 1.
Effect of GCA derivatives on mosquito reproduction
| Short name | Chemical description | Follicle size ± SEM (μm) | Statisticsa | Statisticsb |
|---|---|---|---|---|
| DMSO | Control | 482.6 ± 4.8 | – | – |
| GCA | Commercial | 291.8 ± 5.6 | *** | ns |
| GCA-1 | Ent 1 | 408.2 ± 8.8 | *** | D*** |
| GCA-2 | Ent 2 | 270.0 ± 7.4 | *** | – |
| GCA-3 | Diasteromer | 433.6 ± 7.3 | ns | D*** |
| GCA-4 | Hydrogenated | 407.7 ± 7.6 | *** | D*** |
| GCA-5 | N-Methyl | 416.3 ± 5.5 | ** | D*** |
| GCA-6 | N-Acyl | 442.7 ± 4.9 | ns | D*** |
| GCA-7 | de-2-F-GCA | 343.8 ± 12.5 | *** | D*** |
| GCA-8 | de-Pyridyl-GCA | 235.1 ± 6.8 | *** | I * |
| GCA-9 | de-4-F-GCA | 312.1 ± 10.3 | *** | D** |
| GCA-10 | thiazole-GCA | 330.8 ± 8.4 | *** | D*** |
| GCA-11 | tBu-GCA | 326.2 ± 9.3 | *** | D*** |
| GCA-12 | 2-Pyridyl-GCA | 287.5 ± 5.4 | *** | ns |
| GCA-13 | 4-CF3-GCA | 315.0 ±10.2 | *** | D*** |
| GCA-14 | GCA-ArCN | 309.5 ± 13.5 | *** | D** |
| GCA-15 | GCA-ArBnNHAc | 375.4 ± 11.6 | *** | D*** |
| GCA-16 | GCA-ArBnAm | 301.5 ± 12.5 | *** | ns |
| GCA-17 | GCA-ArCF3 | 230.4 ± 5.2 | *** | I * |
| GCA-18 | GCA-ArAmPip | 275.3 ± 5.3 | *** | ns |
| GCA-19 | GCA-ArAmHept | 243.4 ± 8.5 | *** | ns |
| GCA-20 | GCA-ArAmNapth | 255.9 ± 5.2 | *** | ns |
| GCA-21 | GCA-ArAmArCF3 | 297.5 ± 16.6 | *** | ns |
a
Statistical comparison between DMSO and GCA derivatives.
b
Statistical comparisons between GCA-2 and other GCA derivatives. Symbol ‘I’ and ‘D’ indicate the increased and decreased activity of GCA derivatives compared to GCA-2. Italics indicates compounds significantly more inhibitory than GCA-2 in this assay. Significance levels are shown as ns: not significant,
*
P<0.05,
**
P<0.01,
***
P <0.001.