. Author manuscript; available in PMC: 2013 Aug 15.

Published in final edited form as: Bioorg Med Chem Lett. 2012 Jul 5;22(16):5177–5181. doi: 10.1016/j.bmcl.2012.06.076

Table 2.

Larvicidal effect of GCA derivatives of 2nd instar mosquito larvae

Name		Ae. aegypti mortality				An. stephensi mortality				Statistics^c
		Mean	SEM	Statistics^a	LC₅₀^d	Mean	SEM	Statistics^b	LC₅₀^d
DMSO	control	0.0	0.0	–		0.0	0.0	–		ns
GCA-1	Ent 1	4.7	2.6	ns		0.0	0.0	ns		ns
GCA-2	Ent 2	18.1	4.0	^**		83.4	2.8	^***		^***
GCA-3	Diasteromer	1.5	1.5	ns		0.0	0.0	ns		ns
GCA-4	Hydrogenated	12.3	2.6	ns		57.5	8.1	^***		^***
GCA-5	N-Methyl	96.2	1.9	^***	0.1	100.0	0.0	^***	0.1	ns
GCA-6	N-Acyl	1.7	1.7	ns		0.0	0.0	ns		ns
GCA-7	de-2-F-GCA	0.0	0.0	ns		0.0	0.0	ns		ns
GCA-8	de-Pyridyl-GCA	0.0	0.0	ns		0.0	0.0	ns		ns
GCA-9	de-4-F-GCA	91.4	7.0	^***	0.2	100.0	0.0	^***	0.2	ns
GCA-10	thiazole-GCA	0.0	0.0	ns		37.6	2.1	^***		^**
GCA-11	tBu-GCA	15.4	4.4	^*		86.4	9.7	^***		^***
GCA-12	2-Pyridyl-GCA	100.0	0.0	^***	0.1	100.0	0.0	^***	0.1	ns
GCA-13	4-CF3-GCA	5.3	5.3	ns		0.0	0.0	ns		ns
GCA-14	GCA-ArCN	0.0	0.0	ns		0.0	0.0	ns		ns
GCA-15	GCA-ArBnNHAc	0.0	0.0	ns		0.0	0.0	ns		ns
GCA-16	GCA-ArBnAm	91.7	1.7	^***	0.2	81.7	4.6	^***	0.1	ns
GCA-17	GCA-ArCF3	5.9	5.9	ns		0.0	0.0	ns		ns
GCA-18	GCA-ArAmPip	100.0	0.0	^***	0.05	100.0	0.0	^***	0.05	ns
GCA-19	GCA-ArAmHept	0.0	0.0	ns		0.0	0.0	ns		ns
GCA-20	GCA-ArAmNapth	0.0	0.0	ns		0.0	0.0	ns		ns
GCA-21	GCA-ArAmArCF3	0.0	0.0	ns		0.0	0.0	ns		ns

Statistical significane levels are shown as ns: not significant,

P<0.05,

^**

P<0.01,

^***

P<0.001.

Statistical comparison between DMSO and GCA derivatives in Ae. aegypti.

Statistical comparison between DMSO and GCA derivatives in An. stephensi.

Statistical comparison between Ae. aegypti and An. stephensi for each GCA derivative.

LC50 (50% the lethal concentration in mM) was determined in Ae. aegypti and An. stephensi.