Figure 4. Proliferation inhibition of hPAEC by natural and synthetic dsRNA.
(A) Concentration dependent inhibition of the hPAEC proliferation upon Poly I:C administration. The line is the best fit to the Hill equation with an IC50 of 2.0±0.3 µg/mL. The bar graph summarizes the effect on hPAEC proliferation of Poly I:C, double-stranded RNA and Λ-DNA treatment. The graphs represent 3 independent experiments, each performed in triplicates (**p<0.01, ***p<0.001 compared to Vehicle control). (B) Histogram summarizing the effect of Poly I:C treatment on the cell number distribution in G1, S and G2/M phase of cell cycle. The graph represents 3 independent experiments of flow-cytometric analysis of propidium iodide stained cells.