Figure 4. Stably or transiently inhibited CTGF expression increases cell migration and invasion.
A. Stably downregulating CTGF enhanced the migration ability of 6–10B shRNA-CTGF-A and B cells in vitro. B. Stably suppressed CTGF elevated in vitro invasiveness of 6–10B shRNA-CTGF-A and B cells. C. Transiently downregulated CTGF dramatically enhanced the ability of 6–10B and HONE1 cells migration in vitro. D. Transiently suppressed CTGF elevated in vitro invasiveness of 6–10B and HONE1 cells. One-way ANOVA was used to determine the differences between two groups. (Original magnification 200×). Data were presented as mean±SD for three independent experiments (*p<0.05).