Figure 1. Localization of somatic mutations in ESCO1, CHTF18, and MRE11A in primary endometrial tumors, relative to important functional domains of the encoded proteins.

Individual somatic mutations are indicated by squares (nonsense mutations) or diamonds (missense mutations). Domain positions are derived from [65], [66], [61], [59], [67]. GAR: Glycine-Arginine-Rich motif; RBD:RAD50 Binding Domain; RFC box: Replication Factor C box.