Table 1. Genes resequenced in the mutation discovery screen.
| Human Gene Symbol | Human Gene Name | Human mRNA Accession Number | Human Protein Accession Number | S. cerevisiae Ortholog | E- value | S. cerevisiae Ortholog Regulates Cohesion |
| APRIN/PDS5B | PDS5, regulator of cohesion maintenance, homolog B | NM_015032.1 | NP_055847.1 | PDS5 | 2E-32 | Yes |
| CHTF8/DERPC | CTF8, chromosome transmission fidelity factor 8 homolog | NM_001039690 | NP_001035236.1 | CTF8 | NA | Yes |
| CHTF18 | CTF18, chromosome transmission fidelity factor 18 homolog | NM_022092.1 | NP_071375.1 | CTF18 | 8E-42 | Yes |
| CSPG6/SMC3 | Structural maintenance of chromosomes 3 | NM_005445.3 | NP_005436.1 | SMC3 | 0.0 | Yes |
| DDX11/CHLR1 | DEAD/H (Asp-Glu-Ala- Asp/His) box polypeptide 11 | NM_030653.2 | NP_085911.2 | CHL1 | 2E-139 | Yes |
| DSCC1/DCC1 | Defective in sister chromatid cohesion 1 homolog | NM_024094.1 | NP_076999.2 | DCC1 | 8E-11 | Yes |
| ESCO1 | Establishment of cohesion 1 homolog 1 | NM_052911.1 | NP_443143.2 | ECO1/CTF7 | 8E-15 | Yes |
| KIAA1212/CCDC88A | Coiled-coil domain containing 88A | NM_018084.3 | NP_060554.3 | RAD61 | 4E-04 | Yes |
| LEO1 | Leo1, Paf1/RNA polymerase II complex component, homolog | NM_138792.2 | NP_620147.1 | MRC1 | 1E-04 | - |
| MRE11A | MRE11 meiotic recombination 11 homolog A | NM_005591 | NP_005582.1 | MRE11 | 2E-130 | Yes |
| NIPBL | Nipped-B homolog | NM_015384.3 | NP_597677.2 | SCC2 | 4E-14 | Yes |
| REC8L1 | REC8 homolog | NM_001048205.1 | NP_005123.1 | SPO69 | 9E-05 | Yes |
| SCC-112/PDS5A | PDS5, regulator of cohesion maintenance, homolog A | NM_015200 | NP_056015 | PDS5 | 6E-32 | Yes |
| SGOL1 | Shugoshin-like 1 | NM_001012409.1 | NP 001012410.1 | SGO1 | NA | Yes |
| SMC1L1/SMC1A | Structural maintenance of chromosomes 1A | NM_006306.2 | NP_006297.2 | SMC1 | 1E-153 | Yes |
| STAG2 | Stromal antigen 2 | NM_006603 | NP_006594.3 | SCC3 | 5E-22 | Yes |
| STAG3 2 | Stromal antigen 3 | NM_012447.2 | NP_036579.2 | SCC3 | 8E-23 | Yes |
| TIMELESS | Timeless homolog (Drosophila) | NM_003920.1 | NP_003911.2 | TOF1 | 1E-11 | Yes |
| TIPIN | TIMELESS interacting protein | NM_017858.1 | NP_060328.2 | CSM3 | 7E-10 | Yes |
| WDHD1/hCTF4 | WD repeat and HMG-box DNA binding protein 1 | NM_007086.1 | NP_009017.1 | CTF4 | 7E-21 | Yes |
| ZC3H13/DING 1 | Zinc finger CCCH-type containing 13 | NM_015070 | NP_055885.2 | PDS1 | - | - |
1
Gene analyzed because it is somatically mutated in colorectal cancer.
2
Implicated in meiotic specific cohesion.