Figure 4. Reduction of HCV(2a) levels by anti-CD81 Ab alone and in combination with BILN-2061 or BMS-790052.

HCV(2a) persistently-infected cell cultures were treated with 5×EC₅₀ concentrations of the indicated HCV inhibitors for 21 days (see Table 1 and Materials and Methods). HCV levels were normalized relative to the level of the DMSO control at each time point. This data is the average of 3 assays. Error bars represent standard deviation. Asterisks indicate statistically significant differences at day 21 from the DMSO day 21 time point (t test P≤0.05). (A) DMSO (solid circles and solid line), anti-CD81 Ab (pierced circles and dashed line), BILN-2061 (solid squares and dashed-dot line), BMS-790052 (pierced squares and solid line), BILN-2061/anti-CD81 Ab (solid diamonds and solid line), BMS-790052/anti-CD81 Ab (solid hexagons and solid line), and BILN-2061/BMS-790052 (pierced diamonds and dashed line).