Figure 1. Rat body mass (A) and daily food intake (B).

Filled boxes are the AL group and open bars are the CR group. Rats were weighed weekly. Weekly food allotment for the CR group was based on AL group’s food intake for the previous week. When rats were ∼3 mo-old, the food intake of the CR group was reduced to 90% of AL for a week, 75% of AL for the following week, and continued at 60–65% of AL thereafter. *P<0.05 AL versus CR group. Data are means. For clarity, SE bars are not included.