Figure 4.

Moderation of amygdala–mPFC relationship. Age moderated the association between amygdala and mPFC activation, suggesting that the nature of the relationship between these regions might differ across developmental stages. Specifically, older individuals (adolescents and young adults) exhibited a negative correlation between amygdala and mPFC activity, such that higher mPFC activation was associated with lower amygdala reactivity. Younger individuals (young children and children) displayed a positive correlation between amygdala and mPFC activity, in which higher mPFC activation was associated with higher amygdala reactivity.