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. Author manuscript; available in PMC: 2013 Jun 3.
Published in final edited form as: J Immunol. 2010 Mar 5;184(7):3401–3407. doi: 10.4049/jimmunol.0901550

Figure 6.

Figure 6

Transient depletion of recipient CD11chi DCs delays donor skin graft rejection in recipients of CD47 KO DST. Established CD11c-DTR BM chimeras and WT B6 BM chimeras received 2 injections of DT at days −8 and −6, DST from WT or CD47 KO bm1 donors at day −7, and skin grafting from bm1 donors at day 0. (A) Flow cytometric analysis of GFP+CD11chi cells in the spleen of CD11c-DTR BM chimeras 2 days after 1st DT or PBS injection (1 day after DST). (B–D) Donor skin graft survival in DT-treated CD11c-DTR BM (CD11c-DTR→B6) chimeras and WT B6 BM (B6→B6) chimeras that received no DST (Non-DST; B), WT DST (C) or CD47 KO DST (D). ***P<0.001; N.S., not significant.