. Author manuscript; available in PMC: 2013 Jun 3.

Published in final edited form as: Crit Care Med. 2009 May;37(5):1567–1573. doi: 10.1097/CCM.0b013e31819df06b

Table 1.

Accuracy of IL-6 and IL-1ra for predicting 48-hour survival by receiver operator characteristic test

Study	Marker	Sensitivity (%)	Specificity^a (%)	Area Under the Curve^b	SEM	95%
Study	Marker	Sensitivity (%)	Specificity^a (%)	Area Under the Curve^b	SEM	Confidence	Interval
Current	IL-6	89	97	0.902	0.093	0.719	0.999
Previous^c	IL-6	61	99	0.898	0.042	0.815	0.979
Current	IL-1ra	46	98	0.866	0.048	0.774	0.959
Previous	IL-1ra	30	100	0.862	0.042	0.780	0.944

IL, interleukin.

Sensitivity and specificity were chosen based on cutoffs favoring specificity to avoid inclusion of animals with low risk of death into the dexamethasone treatment subgroup;

area under the curve defines value of the given marker as a diagnostic test for outcome;

calculated based on the data from Osuchowski et al (14).