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Central nervous system receptor binding data for mitragynine.
| Percentage inhibition of radioligand binding by mitragynine at selected receptor systems |
| Adenosine A2A: 65.66 |
| Adrenergic (Alpha 2): 61.92 |
| Dopamine D2s 54.22 |
| Opioid, mu 89.52 |
| Opioid, kappa 90.21 |
| Opioid, delta 7.00 |
| Serotonin, 5HT2C 58.77 |
| Serotonin, 5HT7 64.41 |
| Dissociation constants for opioid receptor binding |
| Mu receptor: 204 ± 26 nM |
| Delta receptor: 2250 ± 120 nM |
| Kappa receptor: 455 ± 47 nM |
