Table 1.
List of chorismate synthase inhibitors
| Sl no | Pathogen name | Inhibitors name | IC50 nM | Ki nM |
|---|---|---|---|---|
| 1 |
Escherichia coli |
(6R)-6-Fluoro-EPSP |
500 and 250000 |
3000 |
| 2 |
Salmonella typhimurium |
2-(3-(-(S)-5-((S)-1-Amino-3-(3-chlorophenyl)-1-oxopropan-2-ylamino)-4-(3-hydroxy-4-methyl-2-nitrobenzamido)-5-oxopentylcarbamoyl)-phenoxy)acetic Acid |
n/a |
720000 |
| 2-(3-(3-((R)-3-((S)-1-Amino-3-(3-chlorophenyl)-1-oxopropan-2-ylamino)-2-(3-hydroxy-4-methyl-2-nitrobenzamido)-3-oxopropylthio) propylcarbamoyl)phenoxy)acetic Acid |
n/a |
2500000 ± 120000 |
||
| N-((S)-6-Amino-1-((S)-1-amino-3-(3-chlorophenyl)-1-oxopropan-2-ylamino)-1-oxohexan-2-yl)-3-hydroxy-4-methyl-2-nitrobenzamide |
n/a |
5700000 ± 1000000 |
||
| N-((S)-1-((S)-1-Amino-3-(3-chlorophenyl)-1-oxopropan-2-ylamino)-1-oxopropan-2-yl)-3-hydroxy-4-methyl-2-nitrobenzamide |
n/a |
6800000 ±2000000 |
||
| 3 |
Streptococcuspneumoniae |
(2E)-6,7-dihydroxy-2-[(2-hydroxy-4-pentoxyphenyl)methylidene]-1-benzofuran-3- one |
220.0 |
n/a |
| (2E)-2-[(4-hexoxy-2-hydroxyphenyl)methylidene]-6, 7-dihydroxy-1-benzofuran-3-one |
320.0 |
n/a |
||
| (2E)-2-[(4-butoxy-2-hydroxyphenyl)methylidene]-6, 7-dihydroxy-1-benzofuran-3-one |
450.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[(2-hydroxy-4-propoxyphenyl)methylidene]-1-benzofuran-3- one |
510.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[[2-hydroxy-4-(2-methylpropoxy)phenyl]methylidene]-1- benzofuran-3-one |
580.0 |
n/a |
||
| ethyl 4-[4-[(E)-(6, 7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-3-hydroxyphenoxy] butanoate |
650.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[(2-hydroxyphenyl)methylidene]-1-benzofuran-3-one |
800.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[(2-hydroxy-3-methoxyphenyl)methylidene]-1-benzofuran-3- one |
800.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[[2-hydroxy-4-(4-hydroxybutoxy)phenyl]methylidene]-1- benzofuran-3-one |
860.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[(2-hydroxy-4-propan-2-yloxyphenyl)methylidene]-1- benzofuran-3-one |
1000.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[(2-hydroxy-4-phenylmethoxyphenyl)methylidene]-1- benzofuran-3-one |
1000.0 |
n/a |
||
| 4-[4-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-3-hydroxyphenoxy] butanenitrile |
1100.0 |
n/a |
||
| 4-[4-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-3-hydroxyphenoxy] butanoic acid |
1100.0 |
n/a |
||
| (2E)-2-[(4-butoxyphenyl)methylidene]-6,7-dihydroxy-1-benzofuran-3-one |
1500.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[[2-hydroxy-4-(6-hydroxyhexoxy)phenyl]methylidene]-1- benzofuran-3-one |
1600.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[(2-hydroxy-4-methoxyphenyl)methylidene]-1-benzofuran-3- one |
1700.0 |
n/a |
||
| 2-[2-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]phenoxy]acetic acid |
1800.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[(2-nitrophenyl)methylidene]-1-benzofuran-3-one |
2000.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[[2-hydroxy-4-(3-hydroxypropoxy)phenyl]methylidene]-1- benzofuran-3-one |
2500.0 |
n/a |
||
| 2-[4-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-3-hydroxyphenoxy]acetic acid |
2600.0 |
n/a |
||
| (2E)-2-[[4-[ethyl(2-hydroxyethyl)amino]-2-methylphenyl]methylidene]-6, 7-dihydroxy-1-benzofuran-3-one |
3400.0 |
n/a |
||
| (2E)-2-benzylidene-6,7-dihydroxy-1-benzofuran-3-one |
3500.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[(2-methylphenyl)methylidene]-1-benzofuran-3-one |
4000.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[(4-nitrophenyl)methylidene]-1-benzofuran-3-one |
1700.0 |
n/a |
||
| (2E)-2-[[4-(diethylamino)-2-hydroxyphenyl]methylidene]-6,7-dihydroxy-1-benzofuran-3-one |
5000.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[(4-imidazol-1-ylphenyl)methylidene]-1-benzofuran-3-one |
5100.0 |
n/a |
||
| (2E)-2-[(2-chlorophenyl)methylidene]-6,7-dihydroxy-1-benzofuran-3-one |
5200.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[(4-pyrrolidin-1-ylphenyl)methylidene]-1-benzofuran-3-one |
5500.0 |
n/a |
||
| (2E)-2-[(4-ethoxyphenyl)methylidene]-6,7-dihydroxy-1-benzofuran-3-one |
5800.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[[4-(trifluoromethyl)phenyl]methylidene]-1-benzofuran-3- one |
7000.0 |
n/a |
||
| (2E)-2-[[4-(diethylamino)phenyl]methylidene]-6,7-dihydroxy-1-benzofuran-3-one |
8500.0 |
n/a |
||
| ethyl 2-[4-[(E)-(6, 7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-3-hydroxyphenoxy] acetate |
10300.0 |
n/a |
||
| 2-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]benzoic acid |
10700.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[(4-methoxyphenyl)methylidene]-1-benzofuran-3-one |
14300.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[(4-hydroxyphenyl)methylidene]-1-benzofuran-3-one |
15000.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[[2-(trifluoromethyl)phenyl]methylidene]-1-benzofuran-3- one |
17300.0 |
n/a |
||
| 4-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]benzoic acid |
24000.0 |
n/a |
||
| (2E)-2-[[4-(dimethylamino)phenyl]methylidene]-6, 7-dihydroxy-1-benzofuran-3-one |
25900.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[(4-morpholin-4-ylphenyl)methylidene]-1-benzofuran-3-one |
>50000.0 |
n/a |
||
| (2E)-2-[(4-fluorophenyl)methylidene]-6,7-dihydroxy-1-benzofuran-3-one |
>60000.0 |
n/a |
||
| (2E)-6,7-dihydroxy-2-[(2-methoxyphenyl)methylidene]-1-benzofuran-3-one |
>60000.0 |
n/a |
||
| [(2S,3R,4R)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3, 4-trihydroxypentyl] dihydrogen phosphate | n/a | n/a |