Skip to main content
PMC home page
Molecular and Cellular Biology logoLink to Molecular and Cellular Biology
. 1986 Oct;6(10):3563–3567. doi: 10.1128/mcb.6.10.3563

Tissue-specific expression of the rat alpha 2u globulin gene family.

J I MacInnes, E S Nozik, D T Kurtz
PMCID: PMC367109  PMID: 2432391

Abstract

The rat alpha 2u globulin gene family encodes approximately 20 low-molecular-weight (20,000) proteins with pIs ranging from 4.5 to 7.9. alpha 2u globulin protein isoforms were detected in the liver and in the submaxillary, lachrymal, preputial, and mammary glands of Sprague-Dawley rats. The hormonal and developmental regulation of alpha 2u globulin synthesis in each of these tissues was unique, and it appears that different alpha 2u gene sets were transcribed in the various tissues.

Full text

PDF

Images in this article

3563Image
on p.3563
3564Image
on p.3564
3564Image
on p.3564
3565Image
on p.3565
3565Image
on p.3565

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Banerji J., Olson L., Schaffner W. A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell. 1983 Jul;33(3):729–740. doi: 10.1016/0092-8674(83)90015-6. [DOI] [PubMed] [Google Scholar]
  2. Chipman R. K., Albrecht E. D. The relationship of the male preputial gland to the acceleration of oestrus in the laboratory mouse. J Reprod Fertil. 1974 May;38(1):91–96. doi: 10.1530/jrf.0.0380091. [DOI] [PubMed] [Google Scholar]
  3. Dolan K. P., Unterman R., McLaughlin M., Nakhasi H. L., Lynch K. R., Feigelson P. The structure and expression of very closely related members of the alpha 2u globulin gene family. J Biol Chem. 1982 Nov 25;257(22):13527–13534. [PubMed] [Google Scholar]
  4. Kurtz D. T., Chan K. M., Feigelson P. Translational control of hepatic alpha2u globulin synthesis by growth hormone. Cell. 1978 Nov;15(3):743–750. doi: 10.1016/0092-8674(78)90260-x. [DOI] [PubMed] [Google Scholar]
  5. Kurtz D. T. Hormonal inducibility of rat alpha 2u globulin genes in transfected mouse cells. Nature. 1981 Jun 25;291(5817):629–631. doi: 10.1038/291629a0. [DOI] [PubMed] [Google Scholar]
  6. Kurtz D. T., Nicodemus C. F. Cloning of alpha 2u globulin cDNA using a high efficiency technique for the cloning of trace messenger RNAs. Gene. 1981 Mar;13(2):145–152. doi: 10.1016/0378-1119(81)90003-2. [DOI] [PubMed] [Google Scholar]
  7. Kurtz D. T. Rat alpha 2u globulin is encoded by a multigene family. J Mol Appl Genet. 1981;1(1):29–38. [PubMed] [Google Scholar]
  8. Laperche Y., Lynch K. R., Dolan K. P., Feigelson P. Tissue-specific control of alpha 2u globulin gene expression: constitutive synthesis in the submaxillary gland. Cell. 1983 Feb;32(2):453–460. doi: 10.1016/0092-8674(83)90465-8. [DOI] [PubMed] [Google Scholar]
  9. O'Farrell P. H. High resolution two-dimensional electrophoresis of proteins. J Biol Chem. 1975 May 25;250(10):4007–4021. [PMC free article] [PubMed] [Google Scholar]
  10. Renkawitz R., Schütz G., von der Ahe D., Beato M. Sequences in the promoter region of the chicken lysozyme gene required for steroid regulation and receptor binding. Cell. 1984 Jun;37(2):503–510. doi: 10.1016/0092-8674(84)90380-5. [DOI] [PubMed] [Google Scholar]
  11. Roy A. K., Neuhaus O. W., Harmison C. R. Preparation and characterization of a sex-dependent rat urinary protein. Biochim Biophys Acta. 1966 Sep 26;127(1):72–81. doi: 10.1016/0304-4165(66)90477-6. [DOI] [PubMed] [Google Scholar]
  12. Roy A. K., Neuhaus O. W. Proof of the hepatic synthesis of a sex-dependent protein in the rat. Biochim Biophys Acta. 1966 Sep 26;127(1):82–87. doi: 10.1016/0304-4165(66)90478-8. [DOI] [PubMed] [Google Scholar]
  13. Shaw P. H., Held W. A., Hastie N. D. The gene family for major urinary proteins: expression in several secretory tissues of the mouse. Cell. 1983 Mar;32(3):755–761. doi: 10.1016/0092-8674(83)90061-2. [DOI] [PubMed] [Google Scholar]
  14. Sippel A. E., Kurtz D. T., Morris H. P., Feigelson P. Comparison of in vivo translation rates and messenger RNA levels of alpha2U-globulin in rat liver and Morris hepatoma 5123D. Cancer Res. 1976 Oct;36(10):3588–3593. [PubMed] [Google Scholar]
  15. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A. 1979 Sep;76(9):4350–4354. doi: 10.1073/pnas.76.9.4350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Walker M. D., Edlund T., Boulet A. M., Rutter W. J. Cell-specific expression controlled by the 5'-flanking region of insulin and chymotrypsin genes. Nature. 1983 Dec 8;306(5943):557–561. doi: 10.1038/306557a0. [DOI] [PubMed] [Google Scholar]

Articles from Molecular and Cellular Biology are provided here courtesy of Taylor & Francis

RESOURCES