Table 4.

In vitro azole resistance in the presence/absence of exposure to azole prophylaxis

Azole prophylaxis exposure	Drugs	No. of isolates	No. (%) of isolates resistantc
Absencea	Fluconazole	72	2 (2.8)
	Voriconazole	72	2 (2.8)
	Posaconazole	72	0
Presenceb	Fluconazole	17	8 (47.0)
	Voriconazole	17	10 (58.8)
	Posaconazole	17	6 (35.3)

^aSpecies included C. albicans (34 isolates), C. parapsilosis (31), C. glabrata (3), and C. tropicalis (4)

^bSpecies included C. albicans (3 isolates), C. parapsilosis (3), C. glabrata (6), and C. tropicalis (5)

^cFluconazole resistance was defined as MIC ≥8 μg/mL for C. albicans, C. tropicalis, and C. parapsilosis, and MIC ≥64 μg/mL for C. glabrata. Voriconazole resistance was defined as MIC ≥1 μg/mL for C. albicans, C. tropicalis, and C. parapsilosis; an epidemiological MIC cut-off value ≥1 μg/mL was used to detect voriconazole resistance in C. glabrata. The resistance species-specific breakpoint for voriconazole was used for posaconazole