Table 1.
Gene–function relationships between miR-153 target genes
| Relevant biological function | p value | Moleculesa |
|---|---|---|
| Fusion of synaptic vesicles | 3.40 × 10–12 | BSN, SNAP25, SYT1, VAMP2 |
| Secretion of neurotransmitter | 4.21 × 10–12 | PTPRN2, SNAP25, SNCA, SYT1, SYT4, VAMP2 |
| Transport of synaptic vesicles | 5.63 × 10–12 | PCLO, SNCA, SYT1, SYT4, VAMP2 |
| Exocytosis | 2.48 × 10–11 | PCLO, SNAP25, SNCA, SYT1, SYT4, VAMP2 |
| Exocytosis by cells | 2.43 × 10–10 | PCLO, SNAP25, SNCA, SYT1, VAMP2 |
| Release of neurotransmitter | 5.64 × 10–10 | PCLO, SNAP25, SNCA, SYT1, SYT4, VAMP2 |
| Excitatory postsynaptic potential | 4.20 × 10–8 | SNAP25, SNCA, SYT1, VAMP2 |
| Presence of fusion pores | 1.13 × 10–7 | SYT1, SYT4 |
| Quantity of synaptic vesicles | 1.82 × 10–7 | PCLO, PTPRN2, SNCA |
| Miniature excitatory postsynaptic currents | 3.00 × 10−7 | SNAP25, SYT1, VAMP2 |
| Synthesis of neurotransmitter | 6.70 × 10−7 | SNAP25, SNCA, SYT1 |
| Exocytosis of vesicles | 7.10 × 10−7 | SNAP25, SYT1, VAMP2 |
| Flux of noradrenaline | 2.38 × 10−6 | SYT1, SYT4 |
| Synaptic transmission | 6.55 × 10−6 | BSN, SNAP25, SNCA, SYT1 |
| Exocytosis of synaptic vesicles | 3.96 × 10−5 | SYT1, VAMP2 |
| Secretion of dopamine | 4.58 × 10−5 | PTPRN2, SNCA |
| Secretion of l-glutamic acid | 5.95 × 10−5 | PTPRN2, SNCA |
| Exocytosis of granules | 7.09 × 10−5 | SYT4, VAMP2 |
| Endocytosis | 1.64 × 10−4 | SNAP25, SNCA, SYT1 |
| Fusion of cellular membrane | 1.92 × 10−4 | SYT4, VAMP2 |
The top 20 relevant biological functions are given
The p values were calculated using the right-tailed Fisher’s Exact Test. The smaller the p value, the less likely a random association and the more significant the association
aNames of proteins involved in each predicted biological function are abbreviated; BSN, bassoon; PCLO, piccolo; PTPRN2, protein tyrosine phosphatase, receptor type, N polypeptide 2; SYT, synaptotagmin; VAMP2, vesicle-associated membrane protein 2