Table 1.
Summary of pharmacokinetic parameters of THC, CBD and 11-OH-THC after a single dose of THC/CBD (4 sprays) alone or in combination with rifampicin
| Parameter | THC/CBD spray alone (n = 12) | THC/CBD spray and rifampicin (n = 12) |
|---|---|---|
| THC | ||
| AUC(0-t) (h*ng/mL) | 9.10 (2.98) | 6.53 (2.70) |
| AUC(0-inf) (h*ng/mL) | 9.86 (3.35)a | 7.53 (2.99) |
| Cmax (ng/mL) | 2.94 (1.21) | 1.88 (1.07) |
| Tmax (h) | 1.01 (0.50-6.02) | 1.75 (1.25-2.57) |
| Kel (h-1) | 0.197 (0.093)a | 0.189 (0.071) |
| t½ (h) | 4.68 (3.42) a | 4.93 (3.91) |
| CL/F (L/h) | 1207 (373)a | 1595 (473) |
| Varea/F (L) | 7625 (4326)a | 10297 (5888) |
| CBD | ||
| AUC(0-t) (h*ng/mL) | 3.23 (2.13) | 1.31 (0.89) |
| AUC(0-inf) (h*ng/mL) | 5.10 (3.06) | 2.15 (0.94)b |
| Cmax (ng/mL) | 1.03 (0.81) | 0.50 (0.37) |
| Tmax (h) | 1.00 (0.50-4.00) | 1.50 (1.00-6.00) |
| Kel (h-1) | 0.148 (0.108) | 0.196 (0.092)b |
| t½ (h) | 10.86 (12.71) | 4.13 (1.65)b |
| CL/F (L/h) | 2817 (1913) | 5966 (3713)b |
| Varea/F (L) | 28312 (19355) | 34790 (20036)b |
| 11-OH-THC | ||
| AUC(0-t) (h*ng/mL) | 18.61 (7.81) | 1.84 (0.79) |
| AUC(0-inf) (h*ng/mL) | 21.59 (8.76) | 2.78 (0.68)c |
| Cmax (ng/mL) | 3.38 (1.95) | 0.45 (0.18) |
| Tmax (h) | 1.38 (0.50-6.02) | 1.75 (1.50-2.57) |
| Kel (h-1) | 0.083 (0.042) | 0.189 (0.074)c |
| t½ (h) | 9.88 (3.89) | 4.19 (1.62)c |
Data presented are mean and (SD) except for Tmax where median and range are shown, an=11; bn=10; cn=11.