Figure 1.

LEDGINs impair replication capacity of HIV-1 produced by HuT78_IIIB cells. HIV-1_IIIB was produced by persistently infected HuT78_IIIB cells in the presence of different concentrations of AZT, raltegravir, CX04328, CX05045, ritonavir or DMSO. (A) Replication capacity of these viruses was assayed in MT-4 cells and data represent virus titer as determined by 50% tissue culture infectivity dose (logTCID₅₀/ml) (mean values ± standard deviations; n = 3). (B) Kinetics of p24 production over successive days was measured for cells treated with 10-fold EC₅₀ of the inhibitors (n = 2). *p<0.05, **p < 0.01; 2-way ANOVA.