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. 2013 May 30;10:57. doi: 10.1186/1742-4690-10-57

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Copyright © 2013 Desimmie et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Reduction of virion replication capacity by LEDGINs is integrase dependent. Detailed analysis of the late effect of LEDGINs on the replication capacity of different HIV-1 strains (NL4.3, LEDGIN-resistant NL4.3_A128Tor HXB2D): (A) in HeLaP4 cells as determined by measuring beta-galactosidase activity 24 hpi (n = 2), (B) in MT-4 cells by calculating the TCID₅₀/ml 5 dpi (n = 4), and (C) in PBMC by monitoring p24 level in the supernatant (n = 2–4). (D) Effect of CX05045 on HIV-2 and SIV_mac251production and infectivity. The replication capacity of the viruses was determined by scoring CPE in MT-4 cells on day 5 postinfection as determined by relative to TCID₅₀/ml (n = 2). All data represent mean values ± standard deviation. **p < 0.001; 2-way ANOVA.