Figure 1.

The NL3^R451C knock-in mutation enhances correlated network activity in the immature hippocampus. (A) Whole cell voltage-clamp (upper traces) and extracellular field recordings (lower traces) of GDPs recorded at P5 in hippocampal slices obtained from WT (black) and NL3^R451C mice (gray). (B) GDPs from the traces in (A) shown on an expanded time scale. (C) Cumulative probability plots of inter-event intervals and areas of inward currents underlying GDPs recorded from WT (n = 24) and NL3^R451C mice (n = 17) between P4 and P9. Curves in the plots referring to WT and R451C KI mice are significantly different (p < 0.01; p < 0.01; K–S test).