Figure 3.

The NL3^R451C knock-in mutation does not affect spontaneous miniature glutamatergic events. (A) Samples traces of mEPSCs recorded from CA3 principal cells at P4–P9 from WT (black) and in NL3^R451C knock-in mice (gray). Below, cumulative probability plots of inter-event intervals (left) and amplitude (right) of obtained from P4–P9 (A), P11–P15 (B), and P27–P35 (C) WT and NL3^R451C knock-in mice. (B) and (C) as (A) but for later developmental stages. Note changes in frequency (but not amplitude of miniature events at P27–P35 (the two curves are significantly different; p < 0.05; K–S test).