Figure 4.

Increased synaptic GABA transient in NL3^R451C knock-in mutant mice. (A) Sample traces of mGPSCs recorded from NL3^R451C mutants (gray) and littermate (black), in the absence (tick line, Control) and in the presence of TPMPA (200 μM; thin line). The amplitudes of mGPSCs from NL3^R451C knock-in mice were normalized to those obtained from WT animals. (B) Each column represents the mean TPMPA-induced reduction in amplitude of mGPSCs in WT (black; n = 8) and NL3^R451C mice (gray; n = 7). ^* p < 0.05.