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The NL3R451C knock-in mutation does not affect single channel conductance and/or the number of GABAA receptor channels. (A) Individual mGPSCs (dotted lines) are shown with the average currents (thick lines) in WT and R451C mice. (B) Current/variance relationships for mGPSCs shown in (A). (C) Summary plots of weighted mean channel conductance and number of GABAA receptor channels in WT (black; n = 8) and in NL3R451C knock-in mice (gray; n = 9).
