Figure 7.

The NL3^R451C knock-in mutation does not alter GABA transporters and tonic GABA_A-mediated inhibition. (A) Left: representative traces of spontaneous GPSCs recorded in a P 12 pyramidal cell in hippocampal slice obtained from a WT animal before (Control), during application of the GAT-1 blocker NO-711 (10 μM) and NO-711 plus picrotoxin (100 μM). Right: all-point histogram of 10 ms traces from the cell recorded on the left in control conditions, in the presence of NO-711 and NO-711 plus picrotoxin. (B) As in (A) but from NL3^R451C KI mutant mouse. (C) Summary data obtained from WT (black; n = 6) and NL3^R451C knock-in mutant mice (gray; n = 7).