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. 2013 May 7;32(11):1626–1638. doi: 10.1038/emboj.2013.100

Figure 7.

Figure 7

Model for 20E regulation of IMD innate immune signalling. 20E controls the IMD innate immune signalling by at least two distinct mechanisms. First, 20E regulates the expression of the peptidoglycan receptor PGRP-LC. This hormonal control involves several ecdysone-inducible transcription factors, including BR-C, Eip78C, Eip93F, Eip74EF, Eip75B, HR46, PNR and SRP. Through this steroid-mediated regulation of the key microbial sensor, immune induction of all AMP genes through the IMD pathway is tightly controlled by prior exposure to this hormone. Through a second mechanism, 20E further regulates the expression of a subset of AMP genes (i.e., Dipt, Mtk and Drs), independent of its control of the receptor PGRP-LC. BR-C, SRP and PNR transcription factors are absolutely required for this PGRP-LC independent hormonal effect. On the other hand, the 20E-inducible nuclear hormone receptor Eip75B negatively regulates the IMD pathway, at least in part, by interfering with PGRP-LC expression.