Figure 3. Cumulative Mortality Hazards for White ARIC Participants in the Highest, Middle, and Lowest Genetic Risk Score (GRS) Qunitiles.
Hazards were estimated from a Cox proportional hazard model adjusted for age, sex, the age-sex interaction, and the ARIC Study Center where data were collected. The dashed line represents sample-wide mortality at the end of follow-up (15%). By the end of follow-up, unadjusted mortality was 12.17% in the lowest GRS quintile, 15.48% in the middle GRS quintile, and 17.32% in the highest GRS quintile.