. Author manuscript; available in PMC: 2014 May 1.

Published in final edited form as: J Clin Lipidol. 2013 Feb 26;7(3):187–193. doi: 10.1016/j.jacl.2013.02.002

Table I.

Criteria for inclusion and exclusion of study participants.

Inclusion Criteria	Exclusion Criteria
Males and females over age 20 years Prior history of statin myalgia Criteria: Patient developed new myalgia, cramps, or muscle aching during statin treatment and, Symptoms resolved within 4 weeks of stopping the statin Willing to limit alcohol intake to two or less drinks daily	Cancer within 5 years of entry Hepatic disease (ALT^* > 2 times normal) Renal disease (creatinine > 2 mg/L) Hypo- or hyperthyroidism (TSH^* > 5 or < 0.01 IU/L) Taking any medications known to alter statin metabolism Cannot discontinue other lipid-lowering medications Regular use of corticosteroids or other drugs known to affect skeletal muscle Receiving intramuscular injections that affect CK^* levels Physical disability preventing strength and exercise performance measurements Women of child-bearing age who are not using an effective birth control technique History of severe rhabdomyolysis (CK > 10 UNL^*)

Inclusion Criteria

Exclusion Criteria

Males and females over age 20 years
Prior history of statin myalgia

Criteria:
1. Patient developed new myalgia, cramps, or muscle aching during statin treatment and,
2. Symptoms resolved within 4 weeks of stopping the statin
Willing to limit alcohol intake to two or less drinks daily

Cancer within 5 years of entry
Hepatic disease (ALT^* > 2 times normal)
Renal disease (creatinine > 2 mg/L)
Hypo- or hyperthyroidism (TSH^* > 5 or < 0.01 IU/L)
Taking any medications known to alter statin metabolism
Cannot discontinue other lipid-lowering medications
Regular use of corticosteroids or other drugs known to affect skeletal muscle
Receiving intramuscular injections that affect CK^* levels
Physical disability preventing strength and exercise performance measurements
Women of child-bearing age who are not using an effective birth control technique
History of severe rhabdomyolysis (CK > 10 UNL^*)

Abbreviations : ALT: alanine aminotransferase; CK: creatine kinase; TSH: thyroid stimulating hormone; UNL: upper normal limit