Longitudinal changes in NMRP expression. A, NMRP expression measured in nonmovement (NO MOVE) scans was elevated relative to healthy control (NL) values at each of the longitudinal time points (TP1: t(18) = 2.108, p = 0.049; TP2: t(18) = 3.180, p = 0.005; TP3: t(12) = 2.786, p = 0.016). Within subjects, these values significantly increased with disease progression (t(17) = 3.487, p = 0.0028; general linear model). B, In the MOVE scans, by contrast, the NMRP elevations reached significance with respect to control values only at the final time point (TP1: t(18) = 0.735, p = 0.472; TP2: t(18) = 1.610, p = 0.125; TP3: t(12) = 3.676, p = 0.003). C, The ΔNMRP activation responses were significantly reduced at the first two time points (TP1: t(18) = −2.272, p = 0.036; TP2: t(18) = −2.274, p = 0.035; TP3: t(12) = −1.713, p = 0.112). NMRP expression in MOVE and NO MOVE increased in parallel over time (r = 0.70, p < 0.001; Bland-Altman correlation). Accordingly, the longitudinal change in ΔNMRP values was not significant (t(17) = 0.002, p = 0.998). *p < 0.05, compared with NL (Student's t test). **p < 0.01, compared with NL (Student's t test).