Figure 5.

Longitudinal changes in NMRP expression. A, NMRP expression measured in nonmovement (NO MOVE) scans was elevated relative to healthy control (NL) values at each of the longitudinal time points (TP1: t₍₁₈₎ = 2.108, p = 0.049; TP2: t₍₁₈₎ = 3.180, p = 0.005; TP3: t₍₁₂₎ = 2.786, p = 0.016). Within subjects, these values significantly increased with disease progression (t₍₁₇₎ = 3.487, p = 0.0028; general linear model). B, In the MOVE scans, by contrast, the NMRP elevations reached significance with respect to control values only at the final time point (TP1: t₍₁₈₎ = 0.735, p = 0.472; TP2: t₍₁₈₎ = 1.610, p = 0.125; TP3: t₍₁₂₎ = 3.676, p = 0.003). C, The ΔNMRP activation responses were significantly reduced at the first two time points (TP1: t₍₁₈₎ = −2.272, p = 0.036; TP2: t₍₁₈₎ = −2.274, p = 0.035; TP3: t₍₁₂₎ = −1.713, p = 0.112). NMRP expression in MOVE and NO MOVE increased in parallel over time (r = 0.70, p < 0.001; Bland-Altman correlation). Accordingly, the longitudinal change in ΔNMRP values was not significant (t₍₁₇₎ = 0.002, p = 0.998). *p < 0.05, compared with NL (Student's t test). **p < 0.01, compared with NL (Student's t test).