Figure 6.

NMRP expression: effects of STN stimulation. A, NMRP expression measured in the NO MOVE scans of PD patients treated with bilateral STN stimulation was abnormally elevated at baseline and during treatment (OFF: t₍₂₀₎ = 3.710, p = 0.001; ON: t₍₂₀₎ = 2.640, p = 0.016). Therapeutic stimulation was associated with a significant reduction in NMRP [NO MOVE] values (t₍₁₃₎ = 3.571, p = 0.003). B, By contrast, NMRP expression measured during MOVE did not differ from control (NL) values in either treatment condition (OFF: t₍₁₄₎ = 1.667, p = 0.118; ON: t₍₁₄₎ = 0.634, p = 0.536). Indeed, STN stimulation did not significantly alter pattern expression in patients scanned while performing the MOVE task (t₍₇₎ = 1.799, p = 0.115). C, In this cohort, ΔNMRP was abnormally reduced at baseline (OFF: t₍₁₄₎ = −2.894, p = 0.012) and a trend-level decrease was present during stimulation (ON: t₍₁₄₎ = −2.138, p = 0.051). The treatment-mediated change in this measure was, however, not significant (t₍₇₎ = −0.849, p = 0.424). *p < 0.05, compared with NL (Student's t test). **p < 0.01, compared with NL (Student's t test).