Inclusion criteria

Age >18 years

Oral prednisone use during the index day and 2 days preceding it

Discharge diagnosis of diabetes or hyperglycemia (ICD-9 codes 249, 250, or 790.29)

Use of NPH or glargine

Exclusion criteria

Blood glucose readings <2 per day

Duration of prednisone use <3 days

Prednisone dosage <10 mg daily

Type 1 diabetes mellitus (identified by discharge ICD-9 codes and medical records review)

Duration of hospital stay <3 days

Serum creatinine ≥3 mg/dL

Clinically relevant hepatic disease

Abbreviations: ICD-9, International Classification of Diseases, Ninth Revision; NPH, neutral protamine Hagedorn.