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Type-I error results for 10,000-replicate simulations conducted using SNP rs6667248 (overall MAF of 0.20) from the schizophrenia GWAS study. Stratification score matches were constructed using significant eigenvectors from principal component analysis.
| Method | Type-I Error | |
|---|---|---|
| α = 0.05 | α = 0.005 | |
| Naive | 0.141 | 0.0290 |
| Stratification Score Matching | 0.048 | 0.0047 |
| GEM | 0.094 | 0.0148 |
| SpectralGEM | 0.112 | 0.0200 |
