Table 4.
Power results based on 10,000-replicate simulations conducted using SNP rs6667248 (overall MAF of 0.20) from the schizophrenia GWAS study. Assumed here is a relative risk of 1.2 per copy of the minor allele. Datasets were generated assuming population stratification but no confounding due to stratification. Stratification score matches were constructed using significant eigenvectors from principal-component analysis.
| Method | Power | |
|---|---|---|
| α = 0.05 | α = 0.005 | |
| Naive | 0.626 | 0.312 |
| Stratification Score Matching | 0.583 | 0.279 |
| GEM | 0.617 | 0.304 |
| SpectralGEM | 0.621 | 0.310 |