Cylinder testing revealed WT mice with an ICH comprised of TLR4-deficient blood and TLR4-deficient mice with a WT ICH had the same functional impairment on day 1 post-ICH. WT mice with TLR4-deficient ICH improved over the 3 days post-ICH, similar to the TLR4-deficient mice with autologous ICH, while the TLR4-deficient mice with WT ICH worsened. **p<0.005. Consistent with the cylinder testing results, open field testing on day 3 post-ICH revealed greater locomotor activity in the WT mice with a TLR4-deficient ICH, n=4/group, * p<0.05.