Table 2. Association of inflammation and histological features with clinical characteristics in the Swedish Watchful Waiting Cohort (N=615).
| Overall, N (%) | Frequency of Clinical Characteristics According to Case/Control Status, N (%) | Frequency of Patients Positive for Feature According to Clinical Tumor Characteristics, N (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Indolent PCa Controls N=228 | Lethal PCa Cases N=387 | Acute Inflamm. | Moderate/Severe Chronic Inflamm. | Simple Atrophy | PAH | SACF | Partial Atrophy | PIN | ||
| Age at Dx, Mean (Std)* | 73.0 (6.6) | 71.9 (6.3) | 74.9 (6.7) | 73.1 (6.4) | 72.8 (6.6) | 73.3 (6.5) | 71.9 (6.9) | 728 (6.8) | 72.1 (6.2) | 72.6 (6.7) |
| p<0.0001 | p=0.96 | p=0.66 | p=0.27 | p=0.03 | p=0.87 | p=0.63 | p=0.55 | |||
| Calendar Year of Dx** | ||||||||||
| 1977-1982 | 22 (3.6) | 13 (3.4) | 9 (3.9) | 4 (18.2) | 8 (36.4) | 12 (54.6) | 3 (13.6) | 6 (27.3) | 2 (9.1) | 1 (4.6) |
| 1982-1986 | 39 (6.3) | 27 (7.0) | 12 (5.2) | 8 (20.5) | 13 (33.3) | 28 (71.8) | 6 (15.4) | 4 (10.3) | 3 (7.7) | 2 (5.1) |
| 1987-1991 | 258 (42.0) | 142 (36.9) | 116 (50.4) | 32 (12.4) | 65 (25.2) | 150 (58.1) | 63 (24.4) | 14 (5.4) | 2 (0.8) | 34 (13.2) |
| 1992-1999 | 296 (48.1) | 203 (52.7) | 93 (40.3) | 40 (13.5) | 72 (24.3) | 175 (59.1) | 53 (17.9) | 14 (4.7) | 4 (1.4) | 43 (14.5) |
| p=0.01 | p=0.52 | p=0.42 | p=0.41 | p=0.18 | p=0.0002 | p=0.001 | p=0.25 | |||
| Tumor Stage* | ||||||||||
| T1a | 252 (41.0) | 195 (50.8) | 57 (24.8) | 32 (12.7) | 57 (22.6) | 156 (61.9) | 49 (19.4) | 14 (5.6) | 6 (2.4) | 18 (7.4) |
| T1b | 362 (59.0) | 189 (49.2) | 173 (75.2) | 51 (14.1) | 101 (27.9) | 209 (57.7) | 75 (20.7) | 24 (6.6) | 5 (1.4) | 61 (16.9) |
| p<0.0001 | p=0.62 | p=0.14 | p=0.30 | p=0.70 | p=0.59 | p=0.37 § | p=0.0004 | |||
| Gleason Score§§ | ||||||||||
| 2-6 | 288 (46.8) | 240 (62.3) | 48 (20.8) | 48 (16.7) | 71 (24.7) | 179 (62.2) | 53 (18.4) | 22 (7.6) | 8 (2.8) | 18 (6.3) |
| 3+4 | 121 (19.7) | 84 (21.8) | 37 (16.1) | 17 (14.1) | 31 (25.6) | 71 (58.7) | 31 (25.6) | 2 (1.7) | 3 (2.5) | 20 (16.5) |
| 4+3 | 86 (14.0) | 41 (10.7) | 45 (19.6) | 11 (12.8) | 28 (32.6) | 49 (57.0) | 19 (22.1) | 8 (9.3) | 0 (0.0) | 19 (22.1) |
| 8-10 | 120 (19.5) | 20 (5.2) | 100 (43.5) | 8 (6.7) | 28 (23.2) | 66 (55.0) | 22 (18.3) | 6 (5.0) | 0 (0.0) | 23 (19.7) |
| p<0.0001 | p=0.009 | p=0.80 | p=0.15 | p=0.85 | p=0.54 | NS | p<0.0001 | |||
| Tumor percent§§ | ||||||||||
| Q1: <2 | 201 (35.7) | 164 (45.9) | 37 (18.0) | 29 (14.4) | 48 (23.9) | 132 (65.7) | 34 (16.9) | 12 (6.0) | 4 (2.0) | 19 (9.5) |
| Q2: >2 - <10 | 152 (27.0) | 98 (27.5) | 54 (26.2) | 21 (13.8) | 42 (27.6) | 93 (61.2) | 37 (24.3) | 14 (9.2) | 4 (2.6) | 16 (10.5) |
| Q3: >10 - <60 | 158 (28.1) | 79 (22.1) | 79 (38.4) | 17 (10.8) | 42 (26.6) | 87 (55.1) | 34 (21.5) | 9 (5.7) | 3 (1.9) | 26 (16.5) |
| Q4: >60 | 52 (9.2) | 16 (4.5) | 36 (17.5) | 6 (11.5) | 13 (25.0) | 26 (50.0) | 8 (15.4) | 2 (3.9) | 0 (0.0) | 15 (28.9) |
| -- | p<0.0001 | p=0.32 | p=0.68 | p=0.01 | p=0.69 | p=0.61 | NS | p=0.0004 | ||
*
P-value from a T-test
**
P-value from a Chi-square test
§
Due to small cell counts, p-values were estimated from a Fisher Exact Test.
§§
P-value from a Chi-square test of trend