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. Author manuscript; available in PMC: 2013 Aug 15.
Published in final edited form as: Dev Biol. 2012 Jun 1;368(2):283–293. doi: 10.1016/j.ydbio.2012.05.026

Fig. 7.

Fig. 7

Influence of Fgfr2S252W expression on skull base and palate formation. (A–D) Mid-sagittal sections of (A) WT, (B) Fgfr2S252W/+ (Apert), (C) NCAp, and (D) MesoAp skulls (calvaria removed) at P0, stained for cartilage (Alcian blue, counterstained with eosin). The black line and arrow in (A) indicate the areas of enlargement of the cranial base (E–H) and palate (I–L), respectively, for all genotypes. The schematic in (A) shows a frontal view of a P0 face with the central vertical dashed line indicating the mid-sagittal plane of section for all panels. The arrow in (B) indicates the perforated palate, enlarged in (J). Scale bar=2 mm. (E–H) Enlargement of the cranial bases from (A–D). Scale bar=1 mm. (I–L) Enlargement of the anterior secondary palates from (A–D). Perforation is only present in the Apert palate (J, arrow). Scale bar=400 μm. ns, cartilage primordium of nasal septum; t, tongue; p, palatal extension of maxillary bone; bo, basioccipital; sos, spheno-occipital synchondrosis; bs, basisphenoid; iss, intersphenoidal synchondrosis; ps, presphenoid.