Table 2.
Cytotoxic activity (IC50 values (μg/mL)) of isolated compounds against selected human cancer cell lines.
| Compounds | IC50 (μg/mL) | |||
|---|---|---|---|---|
| MCF-7 | Ca Ski | HCT-116 | MRC-5 | |
| Curzerenone (1) | 40.0 ± 0.5 | 8.9 ± 0.7 | 53.0 ± 1.5 | 20.0 ± 1.2 |
| Neocurdione (2) | 53.5 ± 1.1 | 46.2 ± 1.1 | 64.0 ± 1.3 | 59.0 ± 0.4 |
| Zederone (5) | >100.0 | >100.0 | >100.0 | >100.0 |
| Alismol (4) | 10.0 ± 0.7 | 8.70 ± 1.1 | 9.0 ± 0.9 | >100.0 |
| Sterols (6–8) | >100.0 | >100.0 | >100.0 | >100.0 |
| *Doxorubicin | 0.05 ± 0.01 | 0.18 ± 0.06 | 0.24 ± 0.04 | 0.40 ± 0.03 |
*Doxorubicin was used as the positive reference compound. Tabulated values are mean ± standard deviation (SD) of three replicates.