Table 1.
CXC Chemokine ligands and their receptors.
| Systematic name | CXC Chemokine | Chemokine receptor | Function | |
|---|---|---|---|---|
| RowSpanEmpty | Human | RowSpanEmpty | Mouse | |
| ELR + chemokines | ||||
| CXCL1 | MGSA-α/GRO-α | GRO/MIP-2 | CXCR2 > CXCR1 | P |
| CXCL2 | MGSA-β/GRO-β | GRO/MIP-2 | CXCR2 | P |
| CXCL3 | MGSA-γ/GRO-γ | GRO/MIP-2 | CXCR2 | P |
| CXCL5 | ENA-78 | GCP2/LIX? | CXCR2 | P |
| CXCL6 | GCP-2 | GCP2/LIX? | CXCR1, CXCR2 | P |
| CXCL7 | NAP-2 | CRA-a,b | CXCR2 | P |
| CXCL8 | IL-8 | Unknown | CXCR1, CXCR2 | P |
|
| ||||
| ELR − chemokines | ||||
| CXCL4 | PF-4 | PF-4 | CXCR3A and B | A/S |
| CXCL9 | Mig | Mig | CXCR3 | A |
| CXCL10 | IP-10 | IP10CRG2 | CXCR3 | A |
| CXCL11 | I-TAC | I-TAC | CXCR3 | A |
| CXCL12 | SDF-1α/β | SDF1/PBSF | CXCR4, CXCR7 | M, P |
| CXCL13 | BCA-1 | BLC | CXCR5 | ? |
| CXCL14 | BRAK | BRAK (BMAC) | ? | A/N/S |
| CXCL16 | SR-PSOX | CXCL16 | CXCR6 | NT/S |
A: angiostatic, M: metastatic, N: NK cell regulation, NT: NKT cell regulation, P: tumor progression, S: tumor suppression.