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In vitro-in vitro correlation table at different dissolution media to select discriminative dissolution media for in vitro drug release.
| Dissolution medium pH | PK parameters | Predicted | Observed | % PE | Ratio |
|---|---|---|---|---|---|
| 1.2 | AUClast (ng/mL ∗ h) | 61.70 | 63.35 | −2.62 | 0.97 |
| C max (ng/mL) | 1.33 | 1.09 | 22.02 | 1.22 | |
|
| |||||
| 4.7 | AUClast (ng/mL ∗ h) | 61.85 | 63.35 | −2.38 | 0.98 |
| C max (ng/mL) | 1.29 | 1.09 | 18.74 | 1.19 | |
|
| |||||
| 6.8 | AUClast (ng/mL ∗ h) | 61.88 | 63.35 | −2.32 | 0.98 |
| C max (ng/mL) | 1.28 | 1.09 | 17.68 | 1.18 | |
