Table 1.
Group | Treatment to adoptive transfer donor (LTT animal) | Treatment to recipient (SLAdd) of naïve kidney (SLAgg) | Survival (days) | ||
---|---|---|---|---|---|
Day -8 | Day -1 | Day -1 | Day 0 | ||
DST 10 ml/kg | 150 rads WBI | Co-administration of PBMCs transfer 2.5×109 cells/kg | Co-transplantation of tolerated kidney graft transfer | ||
A | (−) | (−) | (+) | (−) | 7, 7, 7 |
B | (+) | (+) | (−) (+) |
(−) (−) |
8, 8, 9 7,10,30 |
C | (+) | (+) | (−) | (+) | 9, 10, 73 |
D | (−) | (+) | (−) | (+) | 4, 10, 46 |
E | (+) | (+) | (+) | (+) | 28, >150, >150 |
LTT : long-term tolerant
DST : donor specific transfusion
WBI : whole body irradiation
PBMCs: peripheral blood mononuclear cells