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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Annu Rev Physiol. 2012 Oct 29;75:423–452. doi: 10.1146/annurev-physiol-040510-130049

Figure 2. preBötC is essential for breathing in adult rats.

Figure 2

Rapid silencing of AlstR-expressing preBötC SST neurons induces persistent (>45 min when mechanically ventilated) apnea in anesthetized or awake adult rats. Traces are plethysmographic recordings. AL administered intracerebrocisternally induces a gradual decline of frequency and tidal volume until apnea develops after several minutes. After ~60 min mechanical ventilation, rats resume spontaneous breathing. From (Tan et al 2008).