Table 2.
Comparisons of Total and Index Scores on the RBANS by Diagnostic and Genotype Groupings
| Cognitive Index | Schizophrenia
|
Normal Controls
|
Genotype, F (P value) | Genotype×Diagnosis, F (P value) | ||||
|---|---|---|---|---|---|---|---|---|
| Val/Val (n=155) | Val/Met (n= 316) | Met/Met (n=104) | Val/Val (n=103) | Val/Met (n=204) | Met/Met (n=98) | |||
| Immediate Memory | 57.2±16.3 | 55.6±14.3 | 56.4±12.9 | 72.1±16.7 | 74.0±18.5 | 70.8±15.1 | 0.32 (0.72) | 1.24 (0.29) |
| Attention | 68.6±17.6 | 66.9±17.2 | 63.7±15.5 | 83.6±19.0 | 86.2±20.7 | 82.9±19.1 | 0.09 (0.92) | 3.15 (<0.05) b |
| Language | 80.2±16.8 | 78.5±15.5 | 80.7±15.0 | 92.2±13.1 | 94.3±13.1 | 92.5±13.7 | 0.03 (0.97) | 1.52 (0.22) |
| Visuospatial/Constructional | 77.8±17.3 | 76.0±20.1 | 74.2±17.9 | 79.6±14.6 | 77.8±15.1 | 74.4±14.6 | 4.25 (<0.01) a | 1.29(0.27) |
| Delayed Memory | 65.6±20.1 | 64.5±18.7 | 63.8±15.1 | 84.8±13.7 | 85.2±15.9 | 83.6±15.6 | 0.32 (0.73) | 0.13 (0.88) |
| Total | 63.4±15.4 | 60.9±13.3 | 62.3±12.8 | 77.5±14.1 | 78.9±15.5 | 75.4±13.6 | 0.51 (0.60) | 2.03 (0.13) |
Note:
a
There were significant genotype effects on Visuospatial/constructional index (F=4.25, p<0.01). Further, there was a linear negative correlation between the number of Met 66 alleles and the Visuospatial/Constructional Index score in controls (p<0.01) and in patients (p=0.07).
b
There was a significant genotype × diagnosis effect on Attention (F=3.15, p<0.05). Patients who were Val homozygous had significantly higher Attention index scores than patients who were Met homozygous (p<0.05). There were no genotype differences in Attention among healthy controls (F=0.82, p>0.05).