Figure 8.

Loss of CSPG receptor PTPRS restores axon outgrowth in vivo. Heart sections from Sham (A, C) or I-R (B, D) operated ptprs +/− (A, B) and ptprs −/− (C, D) mice were stained for TH (green) to identify sympathetic nerve fibers and fibrinogen (red) to identify the infarct. Scale bar, 100 μm. Sham hearts of both genotypes (A, C) exhibit normal innervation. In contrast, the infarct is denervated in ptprs+/− hearts (B), but hyperinnervated in ptprs−/− hearts (D). E, Quantification of TH-positive fiber density within the LV of sham and I-R operated (infarct and peri-infarct) animals 10 d post surgery (mean ±SEM, n = 5 mice/group; two-way ANOVA, **p < 0.01, ***p < 0.001).