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Effect of various treatments injected intracerebroventricularly (icv) on activity of heme oxygenase (HO; n=5). Hemin significantly induced the activity of HO and Zn protoporphyrin IX (ZnPPIX) and significantly inhibited the activity of HO. Student’s t-test, **P<0.01 for hemin group vs. control group; ##P<0.01 for ZnPPIX group vs. control group. ZnPPIX, Zn protoporphyrin IX; ACSF, artificial cerebrospinal fluid.
