Table 6.
Laboratory indices of nutritional sufficiency in MSUD children as mean (SD) values.
| Reference range | MSUD baseline | Study formula (N = 9)
|
|||
|---|---|---|---|---|---|
| 6 months | 12 months | ANOVA p value | |||
| Hemoglobin (g/dL) | 11–14.5 | 12.1 (1.2) | 12.6 (0.9) | 12.7 (0.5) | NS |
| Mean corpuscular volume (fL) | 74.0–96.0 | 82.8 (4.8) | 80.5 (2.9) | 82.4 (2.5) | NS |
| Platelet count (×103/μL) | 150–450 | 382.6 (98.0) | 362.8 (94.6) | 385.0 (97.6) | NS |
| Absolute lymphocyte count (cells/μL) | 1100–5900 | 5185.6 (1498.6) | 5632.2 (1436.1) | 5202.0 (845.7) | NS |
| Sodium (mEq/L) | 135–145 | 138.4 (1.7) | 137.3 (1.6) | 139.3 (3.0) | NS |
| Potassium (mEq/L) | 3.4–5.4 | 4.7 (0.4) | 4.5 (0.2) | 4.5 (0.3) | NS |
| Calcium (mg/dL) | 8.5–10.6 | 9.8 (0.3) | 9.7 (0.3) | 9.8 (0.5) | NS |
| Selenium (μg/L) | 110–160 | 56.7 (10.9) | 89.0 (22.0)a | 83.4 (11.0)a | 0.0002 |
| Zinc (μg/L) | 670–1240 | 738.6 (150.0) | 753.1 (131.9) | 812.0 (112.4) | NS |
| Urea nitrogen (mg/dL) | 4–15 | 8.8 (3.7) | 9.8 (2.9) | 9.7 (2.7) | NS |
| Creatinine (mg/dL) | 0.2–0.5 | 0.4 (0.1) | 0.3 (0.1) | 0.4 (0.1) | NS |
| Alkaline phosphatase (IU/L) | 150–380 | 199.9 (46.0) | 214.7 (45.7) | 209.0 (29.8) | NS |
| Total bilirubin (mg/dL) | 0.2–1.0 | 0.5 (0.2) | 0.5 (0.2) | 0.3 (0.1) | NS |
| Albumin (g/dL) | 3.2–4.7 | 4.5 (0.3) | 4.5 (0.2) | 4.5 (0.3) | NS |
| Immunoglobulin G (mg/dL) | 452–1207 | 573.3 (243.0) | 695.4 (240.6) | 700.5 (212.3) | NS |
| Total 25-hydroxyvitamin D (ng/mL) | 20–100 | 35.0 (11.9) | 36.8 (11.6) | 48.9 (14.9) | NS |
| Iron (μg/dL) | 20–124 | – | – | 66.5 (17.4) | na |
| Ferritin (ng/mL) | 7–140 | – | – | 44.1 (20.1) | na |
| Vitamin B12 (pg/mL) | 200–800 | – | – | 1620.4 (419.3) | na |
| Red blood cell folate (ng/mL) | 280–791 | – | – | 669.2 (51.8) | na |
a
Different than baseline value (Tukey post-test p < 0.01); NS, not significant (ANOVA p > 0.05); na, not applicable.