Table 1. Changes in the decay of the high K+ evoked Ca2+ transient in putative nociceptive cutaneous DRG neurons.
Neurons were challenged with high K+ (30 mM, 4s). T25, T50, T75 and T90 are the time to 25, 50, 75 and 90% decay of the peak increase evoked with high K+. Data were analyzed with a mixed design two-way ANOVA, which indicated that there were significant main effects associated with treatment (p < 0.01) and time (p < 0.01), as well as significant interaction between the two (p < 0.01). The Holm-Sidak test was used for post hoc comparisons. As our primary interest was the impact of treatment on the rate of decay, we have only provided the results of the comparisons within each time domain compared to naive.
Treatment | n | T25 (s) | T50 (s) | T75 (s) | T90 (s) |
---|---|---|---|---|---|
Naïve | 41 | 4.66 ± 0.5 | 19.43 ± 2.4 | 50.36 ± 8.2 | 184.45 ± 21.0 |
CFA | 36 | 3.08 ± 0.3** | 36.93 ± 5.2** | 98.19 ± 13.4** | 280.63 ± 26.3** |
Naïve Post CPA | 13 | 15.37 ± 5.9** | 82.45 ± 17.0** | 167.7 ± 28.2** | 273.75 ± 34.8 |
CFA Post CPA | 12 | 9.25 ± 3.7 | 142.56 ± 39.3** | 222.07 ± 47.4** | 304.6 ± 61.8 |
Naïve Post CCCP | 11 | 15.00 ± 1.09** | 22.14 ± 1.55** | 42.42 ± 2.9** | 66.46 ± 4.85** |
Naïve Post Na+ Free | 11 | 4.46 ± 0.6 | 31.29 ± 5.93 | 192.62 ± 33.77** | 331.33 ± 39.84** |
is p < 0.01.