Table 2.
Univariate and multivariate analysis for factors associated with liver fibrosis
| Characteristics | Beta (95% CI) | P | Adjusted beta (95% CI) | P |
|---|---|---|---|---|
| Age at biopsy |
0.035 (0.018, 0.052) |
< 0.001 |
0.018 (0.001, 0.036) |
0.044 |
| Male |
0.046 (-0.597, 0.506) |
0.870 |
|
|
| HBeAg-positive |
-0.496 (-0.943, -0.048) |
0.030 |
|
|
| AST (IU/mL) |
0.001 (-0.001, 0.004) |
0.363 |
|
|
| ALT (IU/mL) |
0.000 (-0.001, 0.001) |
0.802 |
|
|
| AST/ALT |
1.881 (1.199, 2.563) |
< 0.001 |
1.085 (0.368, 1.803) |
0.003 |
| AFP (ng/mL) |
0.012 (0.001, 0.023) |
0.026 |
|
|
| Bilirubin (mg/dL) |
0.142 (-0.168, 0.452) |
0.367 |
|
|
| GGT (IU/L) |
0.006 (0.002, 0.009) |
0.003 |
|
|
| Albumin (g/dL) |
-1.440 (-2.839, -0.042) |
0.044 |
|
|
| Platelet (×103/mm3) |
-0.012 (-0.015, -0.009) |
< 0.001 |
-0.009 (-0.013, -0.005) |
< 0.001 |
| Prothrombin time prolongation (sec) |
0.781 (0.404, 1.157) |
< 0.001 |
0.449 (0.098, 0.800) |
0.012 |
| White blood cell (×103/mm3) |
0.049 (-0.093, 0.192) |
0.495 |
|
|
| Hemoglobin (g/dL) |
0.053 (-0.125, 0.231) |
0.558 |
|
|
| Alpha-1 globulin (g/dL) |
-0.898 (-2.683, 0.886) |
0.322 |
|
|
| Alpha-2 globulin (g/dL) |
-0.505 (-1.746, 0.736) |
0.423 |
|
|
| Beta globulin (g/dL) |
-0.808 (-2.160, 0.545) |
0.240 |
|
|
| Gamma globulin (g/dL) |
0.214 (-0.327, 0.754) |
0.436 |
|
|
| Albumin/Globulin | -0.422 (-1.180, 0.335) | 0.273 |