Levels of the neuroinflammatory cytokines (a) IL-6 and (b) TNFα in Aβ25–35-injected PLTP-KO mice. WT and PLTP-KO mice, supplemented in vitamin E (KOE) or not (KO), received an i.c.v. injection of sterile water (V) or Aβ25–35, 3 nmol (Aβ3). They were killed after 7 days. The contents in inflammatory cytokines IL-6 and TNFα were measured in temporal cortex homogenates by flow cytometry. One-way ANOVA: F(4,23)=3.89, P<0.05, n=4–6 in panel (a); F(4,23)=3.59, P<0.05, n=4–6 in panel (b). *P<0.05, **P<0.01 vs V-treated WT group; φP<0.05 vs V-treated PLTP-KO group; Bonferroni's test.