Figure 1.

Replication results: ADORA2A, SLC6A3, and BDNF. (a) The recreated results from Hohoff et al (2005) (ADORA2A). T/T homozygotes had significantly higher ratings of Anxiety during the 10- and 20-mg drug sessions as compared with heterozygotes. (b) The results from the replication sample. No differences in anxiety between genotypes groups in the replication sample were observed. (c) The recreated results for DEQ Feel from Lott et al (2005) (SLC6A3). Participants with the 9/9 genotype showed less response to amphetamine when compared with heterozygotes and 10/10 homozygotes. (d) The results from the replication sample. All genotype groups showed the same pattern of response. (e) The recreated results from Flanagin et al (2006) (BDNF) for POMS Arousal. Val/val homozygotes showed more pronounced response to amphetamine when compared with val/met+met/met groups. (f) the results from the replication sample. Both the val/val and val/met+met/met groups showed similar responses to amphetamine. *P<0.05, **P<0.001, ***P<10⁻⁴.