Table 1. Summary of Recreated Original and Replication Analyses.

Study	Gene	Polymorphism	Outcome measures	Recreated originalP (dose × genotype ANOVA)	N (mixed/Caucasian)	ReplicationP (dose × genotype ANOVA)	N (mixed/Caucasian)
Hohoff et al (2005)a	ADORA2A	rs5751876	POMS Anxiety	0.041	98 (M)	0.624	281 (C)
Lott et al (2005)a	SLC6A3	3′ UTR VNTR	DEQ Feel	0.006	84 (M)	0.597b	273 (C)
			ARCI LSD	0.007	86 (M)	0.023b	272 (C)
			Diastolic BP	0.037	95 (M)	0.581b	284 (C)
Flanagin et al (2006)a	BDNF	rs6265 (pooled)	POMS Arousal	0.01	94 (M)	0.862	276 (C)
			ARCI BG	0.023	94 (M)	0.543	278 (C)
			Heart rate	0.023	94 (M)	0.791	290 (C)
Lott et al (2006)a	SLC6A4	Intron 2 VNTR	ARCI MBG	0.046	98 (M)	0.352	279 (C)
Veenstra-VanderWeele et al (2006)a	CSNK1E	rs135745	DEQ Feel	0.038	88 (M)	0.267	279 (C)
			ARCI MBG	0.008	89 (M)	0.109	278 (C)
Dlugos et al (2007)a	SLC6A2	rs47958	POMS positive mood	0.019c	90 (M)	0.562c	289 (C)
			POMS Elation	0.01c	90 (M)	0.278c	289 (C)
Dlugos et al (2009)	SLC6A2	rs36017	POMS Elation (gender cov)	0.154	156 (C)	0.57	170 (C)
			POMS vigor	0.041	156 (C)	0.334b	170 (C)
	SLC6A2	rs1861647	POMS Elation (gender cov)	0.137	155 (C)	0.875	170 (C)
			POMS vigor	0.006	155 (C)	0.116b	170 (C)
Hamidovic et al (2009)	DRD2	rs12364283 (pooled)	Stop RT	0.008	89 (C)	0.644b	122 (C)
Dlugos et al (2010)	FAAH	rs3766246	POMS Arousal (gender cov)	0.013	154 (C)	0.123b	173 (C)
			POMS fatigue	0.009b	155 (C)	0.187b	173 (C)
	FAAH	rs2295633	POMS Arousal (gender cov)	0.022	155 (C)	0.369b	173 (C)
			POMS fatigue	0.011	156 (C)	0.478b	173 (C)
Hamidovic et al (2010a)	COMT	rs4680	DSST	0.008	149 (C)	0.734	176 (C)
Hamidovic et al (2010b)	SLC6A3	rs460000 (pooled)	ARCI Amphetamine	0.015	152 (C)	0.03	169 (C)
			ARCI MBG	0.025	152 (C)	0.342b	169 (C)
Dlugos et al (2011)	OPRM1	rs510769	ARCI MBG	0.031b	162 (C)	0.204b	171 (C)
			ARCI A	0.019b	162 (C)	0.571b	171 (C)
	OPRM1	rs2281617 (pooled)	ARCI MBG	0.01b	162 (C)	0.340b	171 (C)
			ARCI BG (gender cov)	0.008b	162 (C)	0.923b	171 (C)

P-values for primary tests in the recreated and replication samples are shown here. N denotes sample size. 'Mixed' refers to samples that include both Caucasians and non-Caucasians.

^aWe were unable to locate the original genotype data files; therefore, we regenotyped subjects. However, because some DNA samples were unavailable, the sample size was smaller and therefore the values are slightly different from the initially published results.

^bGreenhouse–Gessier correction when Mauchly's Test of Sphericity P<0.05.

^cKruskal–Wallis test.